A single academic center performing a high rate of surgical
therapy, including total laryngectomy, to treat advanced-stage laryngeal cancer
had a higher 5-year survival rate than national levels in a small study. Dr Blake
Joseph LeBlanc, of Louisiana State University (LSU) Health-Shreveport and
co-authors evaluated survival rates at their institution for primary surgical
treatment of advanced-stage tumor with outcomes in the National Cancer Database
(NCDB).
In an analysis of 165
patients with laryngeal cancer in the LSU Health tumor registry from 1998 to
2007, 48 (29%) had clinically early-stage (I/II) disease and 117 (71%) had
advanced-stage (III/IV) disease.
Of the 117 patients with advanced-stage disease, 64 (55%)
underwent primary surgical therapy to include total laryngectomy or
pharyngolaryngectomy .Data from the NCDB shows the national rate of
laryngectomy declined from 60% in the 1980s to 32% in 2007.
Five-year survival for stage IV was at LSU was 56% compared
with 32% nationally.
The authors noted "This study suggests that initial
surgical therapy for advanced-stage disease may result in increased survival compared
with organ preservation".
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