Heartburn caused by gastric reflux is a risk factor for laryngopharyngeal cancer

Gastric reflux can reach the upper airway, inducing cellular damage in the epithelial lining. This may be a risk factor for development of laryngopharyngeal squamous cell carcinoma although the medical literature is inconclusive. Frequent heartburn caused by gastric reflux was found to increase the risk for development of throat cancer, and over-the-counter antacids medication may provide protection from it, according to a new study  published in the journal of Cancer Epidemiology, Biomarkers and Prevention.

Researchers from Brown University studied heartburn incidence and medication use in 631 patients with squamous cell cancers of the throat and vocal cords who were not heavy smokers or drinkers, matching them with 1,234 healthy controls.

The investigator found that individuals who had reported a history of frequent heartburn were 78% more likely to have cancer than those who did not. Those with frequent heartburn who took antacids reduced their risk for cancer by 41%, compared with those whose heartburn was not treated.

There was no reduced risk among those taking proton pump inhibitors (i. e., Prilosec, Nexium, Prevacid, Aciphex) or histamine H2 receptor antagonists (i.e., Pepcid, Tagamet, Zantac). However, this may be because those who took such medications were likely to have had severe acid reflux, and not because those drugs are ineffective. The authors recommended that further studies are needed to clarify the possible chemopreventive role of antacid use for patients with gastric reflux.

Michael Douglas shares his treatment experiences for throat cancer and its association with sexually transmitted HPV.

Michael Douglas underwent chemotherapy and radiation treatment in 2011 for stage four throat cancer. He described his difficult personal experiences on the road to recovery in a recent interview. Douglas was shaken when he was diagnosed with late-stage cancer in 2010 after it took his physicians nine months to make the diagnosis. In an interview with the Guardian newspaper, Michael Douglas said that the throat cancer he was diagnosed three years ago was associated with HPV human papillomavirus (HPV) which can be transmitted during oral sex. Through this revelation Douglas pushed the disease onto the mind of millions of Americans who may have become concerned about this cancer for the first time. 

His first symptoms were a sore tooth that resembled a dental infection. He was seen by a periodontist and an otolaryngologist who repeatedly gave him antibiotics without any effect on the pain. After the clinicians assured him that he is better he left to an overseas vacation and only upon his return did another physician discover a walnut-size tumor at the base of his tongue. A biopsy of the tumor lead to the diagnosis of a stage-four throat cancer.

Douglas immediately underwent a grueling eight-week program of chemotherapy and radiation. He was able to avoid a feeding tube but still lost 45 pounds in the process. During the radiation treatment, Douglas was too weak to move around, and stayed confined to a sofa at his home. He currently feels rejuvenated with a new lease on life and is be back at work making movies again.

                                                

                    Michael Douglas in 2011 while receiving chemotherapy and radiation

The HPV Type 16, is also known to cause cervical cancer in women. Unfortunately there no early oral screening test for HPV such as the Pap test. The lack of a screening test for oral HPV means that a doctor should be seen as soon as symptoms appear: a lump in the neck, a sore throat or ear pain that persists for two weeks.

There are currently no studies showing that vaccines to prevent cervical cancer from HPV Types 16 and 18,  also prevent HPV related oral cancer. However, these vaccines are recommend for boys and young men.

Most head and neck cancers are caused by tobacco and alcohol. The overall number of cancer caused by tobacco and alcohol are decreasing, while those associated with HPV are increasing. The cancer caused by HPV generally occurs near the base of the tongue; a difficult site to see and test.  

A saliva test can detect an oral HPV infection. However it is not very helpful because 85% of individuals may be colonized with a variety of HPV types and less than 1% of individuals with HPV 16 eventually develop throat cancer.

Currently about a quarter of head and neck cancer are caused by HPV and it is associated with 80% of tonsillar cancer. About 25,000 cases a year are diagnosed in the United States, compared with 226,000 lung cancers. However, it is growing in importance as smoking-related oral cancers decline.Patients with  positive cancer associated with HPV have a lower risk of dying compared to those with HPV-negative cancer.

The growing frequency in oral sex may have contributed to the increase in cancer caused by HPV. Men are twice as likely as women to get it, and it is more common among whites than blacks. Straight men are more likely to get the cancer than gay men perhaps because there may be more HPV in vaginal fluid than on the penis.

Michael Douglas visiting Jerusalem for his son's bar-mitzva on May 2014

Human papilloma virus (HPV) as a cause of laryngeal cancer: new treatment options.

HPV-related head and neck cancers occur mainly in the oropharynx ( tonsils and the back of the tongue ).  However, a 2013 study from China found HPV infection, especially infection due to the high-risk type HPV-16, was found to be significantly associated with the risk of laryngeal squamous cell carcinoma.

Knowing whether one’s cancer was caused by HPV may help physicians determine the patient prognosis and survival.  Head and neck cancers caused by HPV infection tend to respond better to current treatments as compared to head and neck cancers caused by tobacco or alcohol use.  There are also new treatment options available to patients whose cancers are caused by HPV . These include vaccine clinical trials and treatment protocols that use less radiation and chemotherapy. These are easier for the patient to tolerate as they may generate fewer side effects.

The only way that head and neck cancers can be evaluated for the presence of HPV is to biopsy the lesion and test it for the presence of HPV DNA.  Patients who have already completed surgery, for head and neck cancer, can find out if their cancer is HPV related if the pathology sample is still available. 

Laryngeal cancer

Anaerobic and microaerophilic bacteria in the biofilm on voice prostheses

Voice rehabilitation with voice prostheses is a standard therapy in laryngectomized patients. Biofilm formation on the surface of the voice prostheses causes device failure and requires frequent replacements. Studies analyzing the biofilm of voice prostheses have mainly focused on fungi and aerobic bacteria. Anaerobic bacteria as an integral part of the biofilms on voice prostheses have not been investigated yet.

Betl et al of the Department of Periodontology, Bernhard Gottlieb School of Dentistry, Vienna, Austria,  performed aprospective pilot study on the occurrence of anaerobic and microaerophilic pathogens in biofilm formation on voice prostheses.

Biofilm samples of 15 voice prostheses were analyzed using a polymerase chain reaction-based hybridization method, searching for the existence of 11 selected anaerobic and microaerophilic pathogens.

In 80% of the voice prostheses, at least one and up to 10 of the tested bacteria were identified. Fusobacterium nucleatum was the most common isolate (73%). Other frequently occurring pathogens were Treponema denticola (40%), Tannerella forsythia (33%), and Eikenella corrodens (33%). There was no correlation between the number of identified bacteria and the indwelling times (mean, 127 days; maximum, 344 days; minimum, 22 days).

This is the first study showing the presence of anaerobic and microaerophilic potential pathogens as part of the biofilm formation on the surface of voice prostheses. Further studies are warranted to find out if these organisms may be responsible for accelerated biofilm formation and reduced lifetime of the voice prostheses.

Anaerobic biofilm

Laryngectomy is performed more often in patients with advanced laryngeal cancer

Zhu and colleagues recently investigated whether having a medical comorbidity influenced the choice of treatment of patients with advanced squamous cell carcinoma of the larynx. Comorbidity is the presence of an underlying pathologic condition that has an impact on a patient's total burden of disease. More than 2/3 of patients with cancer have a comorbid condition, and up to one-third of these patients have 2 or more, with hypertension, cardiovascular disease, and pulmonary disease among the most prevalent.

The study evaluated 16 849 patients from more than 1400 medical centers diagnosed with primary invasive advanced squamous cell carcinoma of the larynx between 2003 and 2008. They were selected from the National Cancer Database.

The study demonstrated that receipt of treatment (chemoradiation vs total laryngectomy) was significantly associated with comorbidity. Patients with comorbidity were more likely to have subtotal or total laryngectomy. Patients were also more likely to undergo laryngectomy if they had stage IV disease and if they had been diagnosed at a teaching or research institution. Patients were more likely to receive chemoradiation if they were diagnosed after 2003 or if they lived in a zip code with a high percentage of high school graduates.

The study is the first that demonstrates that patients with advanced laryngeal cancer with one or more comorbidities are more likely to receive surgery than chemoradiation compared with patients without any comorbidity. Previous studies have demonstrated better survival in patients with advanced laryngeal cancer who had been treated with surgery compared with those without.

This study supports the superiority of laryngectomy even in presence of comorbidity.  Even though patients with a comorbidity were less healthy initially their outcome was better after laryngectomy than those who received chemoradiation.

A new study illustrates the safety and efficacy of transoral robotic surgery for supraglottic laryngectomy

Transoral, minimally invasive organ preservation surgeries are being increasingly used for treatment of laryngopharyngeal carcinomas to avoid the toxicities of combined chemotherapy and radiation therapy regimens. A study by Ozer and colleagues from Ohio Medical Center in Columbus investigated the efficacy, safety, and functional outcomes of transoral tobotic surgery (TORS) supraglotic laryngectomy.
The preliminary study examined the outcomes of 13 of head and neck cancer patients with tumors located in the supraglottic region which is the region of the throat between the base of the tongue and just above the vocal cord. The study found that the use of robot-assisted surgery to remove these tumors through the mouth took only about 25 minutes on average, and that blood loss was minimal - a little more than three teaspoons, or 15.4 milliliters, on average, per patient. No surgical complications were encountered and 11 of the 13 patients could receive oral diet within 24 hours. If, on the other hand, these tumors are removed by performing open surgery on the neck, the operation can take at least 4 hours to perform, require 7 to 10 days of hospitalization on average and require a tracheostomy tube and a stomach tube.The results were published recently in the journal Head and Neck. According to the authors The transoral robotic method enables shorter surgery, less time under anesthesia, a lower risk of complications and shorter hospital stays for these patients and no external surgical incisions for the patient.

Transoral robotic surgery

Necrotizing fasciitis-a newly recognized complication of laryngectomy

Necrotizing fasciitis (NF) was recently recognized as a new post surgical complication of laryngectomy. NF is an unusual, life threatening, rapidly advancing serious infection characterized by widespread fascial and subcutaneous tissue necrosis and gangrene of the skin. It most commonly affects the extremities, abdominal wall and perineum, whereas cervical NF is rare. NF of the head and neck is often caused by both aerobic and anaerobic microorganisms found in the upper aerodigestive tract. Usually, cervical NF originates from odontogenic, tonsillar and pharyngeal infection, and it is very rarely a complication of surgical procedure. Without immediate surgical treatment, cervical NF leads to mediastinitis and fatal sepsis. There was only one case of cervical NF after total laryngectomy described in the literature. Hadzibegovic and colleagues recently reported two additional cases of cervical NF after total laryngectomy, selective neck dissection and primary vocal prosthesis insertion. In both cases, the infection spread to thoracic region and in one of the patients NF was associated with Lemierre's syndrome ( thrombosis of the internal jugular vein). In both patients, vocal prosthesis was inserted during the infection and did not influence the healing process.

CT scan of the neck demonstrates gas in the soft tissue of the left side of the neck associated with necrotizing fasciitis.

Michael Douglas's videos about the importance of early diagnosis of oral cancer and his recent lecture about his battle with cancer

Michael Douglas who is an oral cancer survivor has released a video that underscores the importance of early diagnosis of oral cancer. It can be watched on YouTube.  Oral cancer is a disease in which malignant (cancer) cells form in the lips, oral cavity, or oropharynx. The number of new cases of oral cancer and the number of deaths from oral cancer have been decreasing slowly. Tobacco and alcohol use can affect the risk of developing oral cancer. Other risk factors are being infected with a certain type of human papillomavirus (HPV), exposure to sunlight (lip cancer only) and being a male.

There is no standard or routine screening test for oral cancer. Screening for oral cancer may be done during a routine check-up by a dentist or doctor. The exam will include looking for lesions, including areas of an abnormal white patch of cells (leukoplakia) and an abnormal red patch of cells (erythroplakia). These lesions on the mucous membranes may become cancerous.

Michael  Douglas presentation at the  International Federation of Head and Neck Oncologic Societies' 5th World Congress event in New York City on July 27, 2014 

Preoperative Chemotherapy, Radiation Improve Survival in Esophageal Cancer

Patients with esophageal cancer who received chemotherapy and radiation before surgery survived, on average, nearly twice as long as patients treated with surgery alone. The findings, from a large randomized trial of neoadjuvant chemoradiotherapy for the disease, were published May 31 in the New England Journal of Medicine.

Dr. Pieter van Hagen of Erasmus University Medical Center in Holland and his colleagues enrolled 368 patients who had cancer of the esophagus or of the junction between the stomach and the esophagus that had not spread to other organs. Patients randomly assigned to the chemoradiotherapy arm of the study received five courses of chemotherapy with carboplatin and paclitaxel plus concurrent external-beam radiation therapy, followed by surgery, usually within 4 to 6 weeks of completing preoperative treatment. Patients treated with carboplatin and paclitaxel chemotherapy plus radiation prior to surgery had a median overall survival of nearly 50 months, compared with 24 months for patients treated with surgery alone. Patients benefited from preoperative therapy regardless of whether they had adenocarcinoma, the most prevalent form of esophageal cancer in the US, or squamous cell carcinoma, the most prevalent form of the disease worldwide.

Ventilation of Neck Breathers Undergoing a Diagnostic Procedure or Surgery

Receiving sedation while undergoing a diagnostic procedure (i.e. colonoscopy) or general anesthesia while undergoing surgery is challenging for neck breathers including laryngectomees.

Unfortunately, most medical personnel including nurses, medical technicians, surgeons and anesthesiologists caring for a laryngectomees before, during, and after surgery are not familiar with their unique anatomy, how they speak, and how to manage their airways. This lack of familiarity is because of the significant success of laryngeal conservation treatment  that has in turn reduced the number of patients undergoing total laryngectomy. As a result many health providers have less contact than ever with laryngectomees. A manuscript explaining the special needs of laryngectomees and other neck breathers is available on this link. 

 Tracheotomy tube

Do front-line emergency staff appreciate the difference between patients with tracheostomy and those who also had laryngectomy?

In an emergency setting it is vital that the medical staff can appreciate the difference between patients who had laryngectomy and are total neck breathers and those who had tracheostomy for another reason and can still breath from their nose.  This is vital so so that oxygen can be administered in an appropriate manner either to the stoma ( in those who are laryngectomees) or to the nose ( in those who are not).  A survey performed in Birmingham England ascertained the level of emergency healthcare personnel's knowledge with regards to distinguishing between a tracheostomy and a laryngectomy patient, and the emergency management of such patients.

Forty-four accident and emergency medical staff (28 doctors, nine nurses and seven paramedics) completed a questionnaire to ascertain (1) their confidence at differentiating between a laryngectomy and tracheostomy stoma; (2) knowledge of the appropriate site for oxygen delivery if needed; and (3) overall level of training on this subject.

The study published in Journal of laryngology and Otology showed that there were significant gaps in knowledge, particularly with regards to fundamental differences between a tracheostomy and a laryngectomy as less than 5 per cent were able to describe the anatomical difference. Only 41 per cent of the participants were able to correctly identified the route of oxygen administration in laryngectomy patients.

The authors concluded that in In this cohort of emergency staff, the fundamental difference between a laryngectomy and a tracheostomy was poorly understood and that this lack of awareness of front-line emergency staff needs to be addressed in order to maximize patient safety.

A video explaining how to recognize and treat total and partial neck breathers is available.

Individuals with oral cancer are colonized with greater number of bacteria and yeast

Changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both local and systemic infections. Researchers from India assessed the microbial flora associated with the surfaces of oral squamous cell carcinoma and compared the oral microbial contents with healthy mucosa. They also assessed the microbial flora from the saliva culture in subjects with oral squamous cell carcinoma and healthy controls.

The study included 30 subjects with oral squamous cell carcinoma and 30 healthy matched controls. The investigators found that oral squamous cell carcinoma sites harbor significantly more bacteria and yeasts compared to the control group. 

The study clearly indicates that the subjects with oral squamous cell carcinoma harbor significantly more microbial flora. The study's implications are that emphasis has to be made to prevent changes in the microbial flora of the oral cavity. This can be achieved by reducing sugar intake, using probiotics when indicated, avoiding unnecessary use of antibiotics, and maintaining good dental and oral hygiene. 

Microscopic view of oral bacteria and yeast 

New tests may Increase detection of oral cancer

Oral cancer has a poor survival rate linked to late detection. Only 60 percent of patients live beyond five years after diagnosis. Among black males, the survival rate is less than 38 percent. Scientists in Taiwan have already developed a new test to measure the amount of carcinogens attached to our DNA just by testing our spit. Researchers at the University of Texas have developed a new portable probe that could be used to diagnose oral cancer. The probe creates three dimensional images of areas within a tissue surface by illuminating the area with a laser. By taking numerous images and layering them on top of one another, it can deliver a large field of view. 

A study of a potential saliva test for oral cancer is also going to be performed at the Michigan StateUniversity College of Human Medicine's Department of Surgery. It is to be done with collaboration with the Delta Dental of Michigan's Research and Data Institute. The study plan to create a simple, cost-effective saliva test to detect oral cancer. 

The study plans to enroll 100-120 patients with white lesions or growths in their mouths and tonsil areas to test. The researchers will be looking for specific biomarkers that were previously identified by researchers at UCLA. These particular biomarkers have been shown in studies to confirm the presence of oral cancer. 

If the clinical trial is successful in helping create a saliva test to detect the biomarker’s presence, doctors and dentists would have a better idea of which patients actually need  biopsies. The test also has the potential to accelerate health care savings, he added, since the number of biopsies can be dramatically reduced.

A probe to collect saliva and detect oral cancer

A woman recovers her voice after 35 years following larynx surgeries

Jan Christian had a traumatic car accident that fractured her windpipe and voice box at the age of seventeen years. Doctors performed surgery to repair her windpipe and larynx enough to let her breathe and swallow, but they couldn't fix her voice. After that she was unable to speak above a muted whisper. Thirty five years later Christian is finally rediscovering what it feels like to be heard after a series of restorative surgeries that used aerospace engineering theories gave her back the gift of speech. The surgeries were performed by Dr. Khosla, the director of the Voice and Swallowing Center at the University of Cincinnati in Ohio. Dr. Khosla rebuilt Christian's windpipe and larynx. Using laser he had to re-break the cartilage and, replace parts of it. He also had to reconstruct the missing vocal cord, using muscle, tissue and fat tissues from other parts of her body. The vocal cord had to be re-built in order to produce sound.

An interview of Christian and Dr. Khosla can be watched.

Importance of patient participation using information from the Internet

Patient input and participation in one's care are extremely important. As a physician who was diagnosed with throat cancer I encountered many instances where my physicians failed to diagnose my condition and my input was instrumental in improving my care. That input often came from information I found on the Internet.

One example relates to the blood pressure I developed 16 month after receiving radiation treatment to my neck. I was initially labeled as suffering from “essential hypertension”, the most common cause of high blood pressure in individuals over the age of 65 years. I suspected that the radiation treatment I had received lead to the development of hypertension, but my physicians dismissed it. I started to check my blood pressure myself and noticed that it frequently spiked to over 190/110. After my physicians were unable to come with the correct diagnosis and treatment for this unstable blood pressure, I started searching the Web for answers. I was fortunate to discover a rare entity called “paroxysmal hypertension” that can result from radiation damage to the carotid artery baroreceptors. Only after I contacted the physician who researched that topic did I finally start to receive adequate treatment for this condition.

Another example was a rash I developed while getting treatment with a beta blocker (Inderal). Skin biopsy labeled the rash as psoriasis. Both my cardiologist and dermatologist did not make a connection between the medication I was taking and the rash. While searching Google Images for pictures of a psoriatic rash I found a picture of a rash labeled as “beta-blocker psoriatic like rash” which lead me to suspect a connection between the medication and the rash. When I consulted my dermatologist and cardiologist about this condition they both admitted that they did not think about it because it was very rare. Happily in my rash subsided after I stopped taking the medication.

My experience as a patient taught me the limitations of medical knowledge and experience of many of my colleagues. They simply do not always know all the answers or do not think about them. It is left to patients to help themselves by searching for the right answer. It is also essential to remember that even those of us who have medical knowledge should only assist the experts in treating us and not do it alone.

A new throat cancer gene discovered

Investigators from the King’s College London, England, and Hiroshima University, Japan, have identified a specific gene that is linked to throat cancer in a genetic study of a family with ten members who have developed this type of cancer.

The study, recently published in the American Journal of Human Genetics, uncovered a mutation in the ATR gene, demonstrating the first evidence of a link between abnormality in this gene and an inherited  form of cancer. The ATR (ataxia telangiectasia and Rad3 related) gene encodes a protein critical to the way cells repair their DNA. This finding illustrates the presence of genetic factors linked to throat cancer and encourages further exploration the role of ATR in other types in cancer.

Researchers performed a genome-wide linkage study in a family with an unusual hereditary condition affecting 24 members of the family over five generations. Characteristics include developmental abnormalities of hair, teeth and nails as well as dilated skin blood vessels. Nearly every person with the condition involved in the study had developed throat cancer (oropharyngeal squamous cell carcinoma) in their 20s or 30s. They uncovered a single mutation in ATR  in all the individuals  with the condition and in none of the unaffected people. Ten of the 13 people with this mutation had developed throat cancer.

A piece of the shoulder blade used to save woman's voice

Reconstruction of the voice box using bone obtained from the shoulder blade prevented total  laryngectomy in a patient with a rare form of cancer. This allowed the patient to keep her voice box including the vocal cords. The patient suffered from  a slow-growing cancer in the cricoid cartilage, a ring that supported her voice box. Of the about 50,000 people diagnosed with laryngeal cancer every year in the U.S., less than 1% have this particular form of cancer.

After removing the cancer Dr. Douglas Chepeha at the Univerity of Michigan Hospital in Ann Arbour who performed the surgery used part of the 59 years old patient’s shoulder blade cartilage to reconstruct her voice box in a surgery at University Hospital in Ann Arbor. It is the first time this type of surgery has been done successfully. According to the surgeon this advance could help many other patients, including cancer patients with oral cancer, those who lose their voices and premature babies who end up with ruined voice boxes after being on a tracheotomy tube too long.

                        A picture explaining the procedure performed to save the voice box

Michael Douglas and wife Catherine Zeta Jones at anniversary of "beating" cancer

Michael Douglas and wife Catherine Zeta Jones was vacationing at Michael's anniversary of beating his oral cancer. The couple was photographed on the beach in Panama. It is good to see Michael return to enjoyable activities with his family after his treatment for cancer. He was diagnosed with oral cancer in August 2010 and received treatment with chemotherapy and radiation.  

Michael Douglas and wife Catherine Zeta Jones 

Oral Cancer is more common in men and smokers

Human papillomavirus (HPV) infection is the main cause of a distinct form of oropharyngeal squamous cell carcinoma that is increasing in prevalence a in the USA.

A recent study By Gillison et al. published in the Journal of American Medicine Association (JAMA) determined the prevalence of oral HPV infection in the USA.

Oral rinses from 5579 men and women aged 14 to 69 years were evaluated by polymerase chain reaction and type-specific hybridization.

The overall prevalence of oral HPV infection was about 7%. The prevalence was three times higher among men than among women as 10.1 % of men were infected orally, compared with 3.6 % of women.  Only 1% (projected estimate of 2 million Americans), were infected with HPV 16, the strain linked to throat cancers and many cases of cervical cancer. Since only less than 10,000 cases of throat cancer caused by HPV 16 are diagnosed every year, most individuals with the oral HPV virus infection do not develop cancer.  

The researchers found a high prevalence of oral HPV at 2 periods of life – between the age 30 to 34 years and 60 to 64 years.  Oral HPV infection was more common among those with a history of any type of sexual contact, increased with number of sexual partners and cigarettes smoked per day.

The increased risk associated with smoking may be due to the weakening of the immune system by smoking which may increase the susceptibility of smokers to infection. Furthermore smoking may also make transmission more likely by damaging the lining of the mouth.

Vaccination against HPV was shown to prevent cervical cancer.  Even though there is no proof yet that HPV vaccination prevent oral cavity oropharyngeal cancer, these findings underscore the importance of vaccination against HPV virus of both males and females.
For more on HPV click this link.

"My voice-a physician's personal experience with throat cancer" was obtained by the University of Southern California Head and Neck Cancer Support Group for their members.

                    

 Members of the University of Southern California Head and Neck Cancer Support Group with the book at their February 4 , 2012 meeting.

Oral, Head and Neck Cancer Awareness Week and the early detection of head and neck cancer

The 15th annual Oral, Head and Neck Cancer Awareness Week occur April 22-28, 2012.  This weeklong series of events is aimed to educate the public about these potentially life-threatening but eminently treatable cancers and to promote prevention, screening and early detection. It is highlighted by the free screenings and related activities held at participating medical centers across the country. The screenings are quick, painless, and designed to advance early diagnosis, which can lead to better outcomes. The locations of the free screening sites are available at the Head and Neck Cancer Alliance internet site which also sponsors the event.

According to the American Cancer Society, an estimated 40,250 new cases of cancer of the oral cavity and throat, and an estimated 7,850 deaths from these cancers, are expected in 2012. 

Most oral cancers arise on the lips, tongue or the floor of the mouth. They also may occur inside your cheeks, on your gums or on the roof of your mouth.

Some signs and symptoms include:

·        A sore in your mouth that doesn't heal or that increases in size

·        Persistent pain in your mouth

·        Lumps or white, red or dark patches inside your mouth

·        Thickening of your cheek

·        Difficulty chewing or swallowing or moving your tongue

·        Difficulty moving your jaw, or swelling or pain in your jaw

·        Soreness in your throat or feeling that something is caught in your throat

·        Pain around your teeth, or loosening of your teeth

·        Numbness of your tongue or elsewhere in your mouth

·        Changes in your voice

·        Bad breath

·        A lump in your neck

Tobacco (including smokeless tobacco) and alcohol use are the most important risk factors for oral, head and neck cancers, particularly those of the tongue, mouth, throat and voice box.  People who use both tobacco and alcohol are at greater risk for developing these cancers than people who use either tobacco or alcohol alone.

Anyone can develop thyroid cancers, although a family history or exposure to radiation is often a factor. Salivary gland cancers do not seem to be associated with any particular cause.

The increase of oral cancer incidence in young adults, a group traditionally at low risk, is attributed to the rise of the human-papillomavirus (HPV), a cancer-causing virus that can be transmitted through oral sex.  Currently 70% of oropharyngeal cancers are caused by HPV infection. According to researchers, patients with HPV-positive oral cancers are more responsive to treatment and have better survival rates than HPV-negative patients.