As of now, no drugs or biologics have
been proven to be effective for the prevention or treatment of COVID-19. There
are many investigational drugs and biologics under investigation for COVID-19.
Hopefully some of them will be available for use in the near future. Some may
be used in severe cases even before they are approved by the FDA.
Antiviral Agents:
- Remdesivir
- Lopinavir/ritonavir
- Rintatolimod
- Toll-like receptor 3 (TLR-3) agonist rintatolimod (Poly I:Poly C12U)
- Ampligen; AIM ImmunoTech)
- Azvudine (nucleoside reverse transcriptase inhibitor)
- Danoprevir (NS3/4A HCV protease inhibitor)
- Favipiravir (viral RNA polymerase inhibitor)
Immunomodulators and Other Investigational Therapies:
- Ifenprodil (NP-120; Algernon Pharmaceuticals) Brilacidin
- Remestemcel-L (Mesoblast Ltd) Eli Lilly and AbCellera are co-developing an antibody treatment .
- Anti-SARS-CoV-2 polyclonal hyperimmune globulin (TAK-888; Takeda) is being developed to treat COVID-19 in high-risk patients.
- Interleukin-6 inhibitors
- Anti-malaria drugs: Hydroxychloroquine and chloroquine
Vaccines
- INO-4800 (Inovio Pharmaceuticals):
- mRNA-1273 (Moderna Inc
- CureVac has an mRNA vaccine in development that is not yet ready for human testing.
- COVID-19 S-Trimer (GlaxoSmithKline and Clover Biopharmaceuticals)
- SARS-CoV-2 vaccine (Johnson & Johnson
- Sanofi is also collaborating with BARDA to develop a vaccine using their recombinant DNA platform.
- Several other vaccines are developed: by Novavax, Codagenix, Applied DNA Sciences and Takis Biotech, and Altimmune, Inc.
To obtain more suggestions for laryngectomees how to cope with COVID-19 pandemic click the Laryngectomee Newsletter link.
Corona virus (COVID-19)
