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Tuesday, July 28, 2020

Impact of active smoking on outcomes in HPV+ oropharyngeal cancer

Researchers from Harvard Medical School, and Cleveland Clinic studied the impact of active smoking on survival in human papillomavirus - positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients from 2001 to 2015.

Among the 484 evaluated patients, 94 (20%) were active smokers, 226 (47%) were former smokers, and 164 (34%) never smoked. Among active smokers, 82 patients (87%) had a ≥10 packs/year and 69 (73%) had a ≥20 pack/year smoking history. Active smoking was a significant predictor of inferior survival and progression-free survival, and ≥20 pack/yeas predicted a decreased effect-size for inferior survival and progression-free survival.

The investigators concluded that active smoking at diagnosis is the most powerful predictor of survival and progression-free survival in patients with HPV(+) OPSC .